Welcome to the “2nd International Conference on Orphan Drugs and Rare Diseases” (ORPHAN DRUGS 2025) slated to convene in Rome, Italy, from March 17 – 19, 2025. This event will provide a platform for global collaboration and exchange of knowledge in the realm of orphan drugs and rare diseases, catering to attendees both onsite and virtually with the theme “Beyond Borders: Uniting for Rare Diseases and Orphan Drugs.